Cleveland ( KLEEV-lənd), officially the City of Cleveland, is a city in the U.S. state of Ohio and the county seat of Cuyahoga County. Located in the northeastern part of the state, it is situated along the southern shore of Lake Erie, across the U.S. maritime border with Canada and approximately 60 miles (100 kilometers) west of Pennsylvania. The largest city on Lake Erie and one of the major cities of the Great Lakes region, Cleveland ranks as the 54th-largest city in the U.S. with a 2020 population of 372,624. The city anchors both the Greater Cleveland metropolitan statistical area (MSA) and the larger Cleveland–Akron–Canton combined statistical area (CSA). The CSA is the most populous in Ohio and the 17th largest in the country, with a population of 3.63 million in 2020, while the MSA ranks as 34th largest at 2.09 million.

Cleveland was founded in 1796 near the mouth of the Cuyahoga River by General Moses Cleaveland, after whom the city was named. Its location on both the river and the lake shore allowed it to grow into a major commercial and industrial center, attracting large numbers of immigrants and migrants. A port city, Cleveland is connected to the Atlantic Ocean via the Saint Lawrence Seaway. Its economy relies on diversified sectors such as manufacturing, financial services, healthcare, biomedicals, and higher education. The GDP for the Greater Cleveland MSA was $135 billion in 2019. Combined with the Akron MSA, the seven-county Cleveland–Akron metropolitan economy was $175 billion in 2019, the largest in Ohio, accounting for 25% of the state's GDP.

Designated as a "Gamma -" global city by the Globalization and World Cities Research Network, Cleveland is home to several major cultural institutions, including the Cleveland Museum of Art, the Cleveland Museum of Natural History, the Cleveland Orchestra, Playhouse Square, and the Rock and Roll Hall of Fame. Known as "The Forest City" among many other nicknames, Cleveland serves as the center of the Cleveland Metroparks nature reserve system. The city's major league professional sports teams include the Cleveland Browns, the Cleveland Cavaliers, and the Cleveland Guardians.